819 research outputs found
Utilising Openair to support multi-stakeholder engagement and the resolution of air quality issues
For key stakeholders to make informed air quality management decisions it is often necessary for in-depth data analysis to be tailored and concisely presented to meet their needs. Given the complexity of sources, the abundance of relevant data (e.g. monitoring, modelling, process data) and the spatial and temporal scale of these issues, the provision of this information can be challenging, particularly with multiple stakeholders requiring varying outputs. Using a case study which investigated PM in the vicinity of a steelworks, this paper 10 will illustrate how Openair (an open-source air pollution analysis package based on the programming language/statistical package R (http://www.openairproject.org/)) can be utilised to analyse relevant air pollution data on a spatial and temporal scale in order to support multistakeholder engagement and the resolution of air quality issues
Extracting antipsychotic polypharmacy data from electronic health records: developing and evaluating a novel process
Background
Antipsychotic prescription information is commonly derived from structured fields in clinical health records. However, utilising diverse and comprehensive sources of information is especially important when investigating less frequent patterns of medication prescribing such as antipsychotic polypharmacy (APP). This study describes and evaluates a novel method of extracting APP data from both structured and free-text fields in electronic health records (EHRs), and its use for research purposes.
Methods
Using anonymised EHRs, we identified a cohort of patients with serious mental illness (SMI) who were treated in South London and Maudsley NHS Foundation Trust mental health care services between 1 January and 30 June 2012. Information about antipsychotic co-prescribing was extracted using a combination of natural language processing and a bespoke algorithm. The validity of the data derived through this process was assessed against a manually coded gold standard to establish precision and recall. Lastly, we estimated the prevalence and patterns of antipsychotic polypharmacy.
Results
Individual instances of antipsychotic prescribing were detected with high precision (0.94 to 0.97) and moderate recall (0.57-0.77). We detected baseline APP (two or more antipsychotics prescribed in any 6-week window) with 0.92 precision and 0.74 recall and long-term APP (antipsychotic co-prescribing for 6 months) with 0.94 precision and 0.60 recall. Of the 7,201 SMI patients receiving active care during the observation period, 338 (4.7 %; 95 % CI 4.2-5.2) were identified as receiving long-term APP. Two second generation antipsychotics (64.8 %); and first -second generation antipsychotics were most commonly co-prescribed (32.5 %).
Conclusions
These results suggest that this is a potentially practical tool for identifying polypharmacy from mental health EHRs on a large scale. Furthermore, extracted data can be used to allow researchers to characterize patterns of polypharmacy over time including different drug combinations, trends in polypharmacy prescribing, predictors of polypharmacy prescribing and the impact of polypharmacy on patient outcomes
Traceability for Mutation Analysis in Model Transformation
International audienceModel transformation can't be directly tested using program techniques. Those have to be adapted to model characteristics. In this paper we focus on one test technique: mutation analysis. This technique aims to qualify a test data set by analyzing the execution results of intentionally faulty program versions. If the degree of qualification is not satisfactory, the test data set has to be improved. In the context of model, this step is currently relatively fastidious and manually performed. We propose an approach based on traceability mechanisms in order to ease the test model set improvement in the mutation analysis process. We illustrate with a benchmark the quick automatic identification of the input model to change. A new model is then created in order to raise the quality of the test data set
Theoretical Evaluations of the Fission Cross Section of the 77 eV Isomer of 235-U
We have developed models of the fission barrier (barrier heights and
transition state spectra) that reproduce reasonably well the measured fission
cross section of U from neutron energy of 1 keV to 2 MeV. From these
models we have calculated the fission cross section of the 77 eV isomer of
U over the same energy range. We find that the ratio of the isomer
cross section to that of the ground state lies between about 0.45 and 0.55 at
low neutron energies. The cross sections become approximately equal above 1
MeV. The ratio of the neutron capture cross section to the fission cross
section for the isomer is predicted to be about a factor of 3 larger for the
isomer than for the ground state of U at keV neutron energies. We have
also calculated the cross section for the population of the isomer by inelastic
neutron scattering form the U ground state. We find that the isomer is
strongly populated, and for the cross section
leading to the population of the isomer is of the order of 0.5 barn. Thus,
neutron reaction network calculations involving the uranium isotopes in a high
neutron fluence are likely to be affected by the 77 eV isomer of U.
With these same models the fission cross sections of U and U
can be reproduced approximately using only minor adjustments to the barrier
heights. With the significant lowering of the outer barrier that is expected
for the outer barrier the general behavior of the fission cross section of
Pu can also be reproduced.Comment: 17 pages including 8 figure
Considering Polymorphism in Change-Based Test Suite Reduction
With the increasing popularity of continuous integration, algorithms for
selecting the minimal test-suite to cover a given set of changes are in order.
This paper reports on how polymorphism can handle false negatives in a previous
algorithm which uses method-level changes in the base-code to deduce which
tests need to be rerun. We compare the approach with and without polymorphism
on two distinct cases ---PMD and CruiseControl--- and discovered an interesting
trade-off: incorporating polymorphism results in more relevant tests to be
included in the test suite (hence improves accuracy), however comes at the cost
of a larger test suite (hence increases the time to run the minimal
test-suite).Comment: The final publication is available at link.springer.co
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Light-Weight Containment for High Energy, Rotating Machines
Developed a lightweight containment system for high-speed composite rotors. The containment device, consisting of a rotatable, composite structure, has been demonstrated to contain the high-energy release from a rotor burst event and is applicable to composite rotors for pulsed power applications. The most important aspect of this design is that the free-floating containment structure dissipates the major loads (radial, torque, and axial) encountered during the burst event, greatly reducing the loads that pass through the stator structure to its attachments. The design results in significant system-level weight savings for the entire rotating machine when compared to a system with an all-metallic containment. Of equal interest to the containment design, the experimental design and instrumentation was very challenging and resulted in significant lessons learned. This paper describes the containment system design, rotor burst test setup, instrumentation for measuring loads induced by the burst event, and a detailed explanation of the successful containment test results and conclusions.Center for Electromechanic
Gender moderates the relationship between empathy and aggressiveness in sport: The mediating role of anger
This research investigated whether gender moderates, and anger mediates, the relationship between empathy (i.e., perspective taking and empathic concern) and aggressiveness in sport. In Study 1, perspective taking and empathic concern were negatively associated with aggressiveness, and this effect was stronger in women compared to men. In Study 2, perspective taking was a negative predictor of aggressiveness and antisocial behavior in sport, and anger mediated these relationships in women, but not in men. Our findings suggest that empathy and emotion-based strategies targeted at reducing aggressiveness in sport need to be tailored for males and females
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Active Magnetic Bearings for Energy Storage Systems for Combat Vehicles
Advanced energy storage systems for electric guns and other pulsed weapons on combat vehicles present significant challenges for rotor bearing design, Active magnetic bearings (AMBs) present one emerging bearing option with major advantages in terms of lifetime and rotational speed, and also favorably integrate into high-speed flywheel systems. The Department of Defense Combat Hybrid Power Systems (CHPS) program serves as a case study for magnetic bearing applications on combat vehicles. The University of Texas at Austin Center for Electromechanics (UT-CEM) has designed active magnetic bearing actuators for use in a 5 MW flywheel alternator with a 318 kg (700 lb), 20000 rpm rotor. To minimize CHPS flywheel size and mass, a topology was chosen in which the rotating portion of the flywheel is located outside the stationary components. Accordingly, magnetic bearing actuators are required which share this configuration. Because of inherent low loss and nearly linear force characteristics, UT-CEM has designed and analyzed permanent magnet bias bearing actuators for this application. To verify actuator performance, a nonrotating bearing test fixture was designed and built which permits measurement of static and dynamic force. An AMB control system was designed to provide robust, efficient magnetic levitation of the CHPS rotor over a wide range of operating speeds and disturbance inputs, while minimizing the occurrence of backup bearing touchdowns. This paper discusses bearing system requirements, actuator and controller design, and predicted performance; it also compares theoretical vs. measured actuator characteristicsCenter for Electromechanic
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